Aldo R. Boccaccini is Professor of Biomaterials and Head of the Institute of Biomaterials at the University of Erlangen-Nuremberg, Germany. He is also visiting Professor at Imperial College London, UK. He holds an engineering degree from Instituto Balseiro (Argentina), Dr-Ing. (PhD) from RWTH Aachen University (Germany) and Habilitation from TU Ilmenau (Germany). The research activities of Prof. Boccaccini are in the field of glasses, ceramics and composites for biomedical, functional and/or structural applications. He is the author or co-author of more than 800 scientific papers and more than 20 book chapters and he has edited five books. His work has been cited more than 30,000 times and he was named in the 2014 and 2018 Highly Cited Researcher lists (Clarivate Analytics). Boccaccini has been a visiting professor at different universities around the world, including Japan, Italy, Spain, Slovenia, Netherlands, Singapore, Germany, Argentina, Austria and Poland. His achievements have been recognized with several awards including the Materials Prize of the German Materials Society (DGM) in 2015. Boccaccini is the editor-in-chief of the journals Materials Letters and Biomedical Glasses, he serves in the editorial board of more than 10 international journals. In 2015 he was elected member of the Council of the European Society for Biomaterials (ESB) and member of the World Academy of Ceramics. He also serves in the Executive Committee of the Federation of European Materials Societies (FEMS), the Review Panel of the German Science Foundation (DFG) and is an international advisor to the Ministry of Science and Technology of Argentina. He has been member of the Basic Science and Technology Division of the Society of Glass Technology (SGT) for more than 10 years. He was elected Fellow of SGT in 2018.

Aldo R. Boccaccini


Institute of Biomaterials, University of Erlangen-Nuremberg
91058 Erlangen, Germany


Originally developed 50 years ago for applications in contact with bone, e.g. as bone substituting and bone filler materials, bioactive glasses (BGs) are being increasingly considered in the tissue engineering field, being investigated both in bone and soft tissue regeneration approaches. The key property enabling such applications in soft tissue repair, e. g. wound healing, is the ability of BGs to enhance vascularization via the action of ionic dissolution products (biologically active ions) [1, 2]. Silicate, phosphate and borate BGs, also combined with biopolymers forming biodegradable composites, will be discussed based on in vitro and in vivo studies in relation to hard and soft tissue regeneration. A variety of bone tissue scaffolds exhibiting highly interconnected pore structure can be fabricated by the traditional polymer replica technique or by additive manufacturing methods. The relatively low mechanical properties of such (highly porous) scaffolds can be counteract by coating the 3D porous structures with natural or synthetic polymers, so that the scaffolds achieve malleable characteristics. The coating and infiltration of scaffolds by biodegradable polymers will be discussed showing a variety of recent results, which highlight that not only the structural integrity of scaffolds is improved but also the scaffolds become “multifunctional” by the addition of ion doped inorganic nanoparticles, e.g. mesoporous particles, as drug carriers [3]. Moreover in-vivo result demonstrating the vascularisation potential of new bioactive glasses will be discussed. In the emerging field of BGs for soft tissue engineering, an overview of their applications in contact with soft tissues will be presented focusing on our current work on Boron containing BGs (borosilicate and borate glasses) with different degradation behaviour and biological activity for hemostasis and skin repair.

References

[1] V. Miguez-Pacheco, et al., Bioactive glasses beyond bone and teeth: emerging applications in contact with soft tissues, Acta Biomaterialia 13 (2015) 1-15.
[2] V. Mourino, et al., Enhancing biological activity of bioactive glass scaffolds by inorganic ion delivery for bone tissue engineering, Curr. Op. Biomed. Eng.10 (2019) 23-34.
[3] E. Boccardi, et al., Uniform surface modification of 3D Bioglass®-based scaffolds with mesoporous silica particles (MCM-41) for enhancing drug delivery capability, Frontiers in Bioengineering and Biotechnology 3 (2015) 177.